Common routes of administration requiring use of a catheter. Osmotic pump implantation in mice and rats ucsf iacuc. Itca 650 is the first investigational osmotic minipump designed for the treatment of t2d. It is generally used intravenously, although subcutaneous, arterial and epidural infusions are occasionally used infusion pumps can administer fluids in ways that would be impractically expensive or unreliable if performed manually by nursing staff. Implantable osmotic release pump anesthesia conduct. If your research requires an additional injection or chronic administration while using an osmotic pump, we offer a guideosmotic pump cannula. The historical development of osmotic systems includes development of the rosenelson pump, the higuchileeper pumps, the alzet and osmet.
The alzet mini osmotic pump model 2001 delivers solutions continuously for 7 days without the need for external connections or frequent handling of animals. Rose nelson pump the pump pushpull osmotic pump advantage rose nelson pump was the first pump produced it was composed of three chambers. Durect corporation manufactures a miniature implantable pump for use in laboratory animals. Chlorpromazine free base clp was chosen as a model drug for this study. Intarcia medici, a tiny implantable pump for drug delivery. Development of ethylcellulose coating on osmotic pump tablets sophie zhai, 1 robert schmitt, 2 jennifer lhotegaston 3 1 the dow chemical company, shanghai, china 2 the dow chemical company, bound brook, nj, usa 3 the dow chemical company, midland, mi, usa.
These devices, when activated by water, can deliver a variety of solutions or suspensions at zeroorder rates for periods of hours up to several weeks. Alzet osmotic pump brain infusion kit 2 instructions and specifications sheet durect corporation offers a series of miniature implantable pumps, alzet osmotic pumps, for use in laboratory animals. Sep 16, 2015 alzet pumps deliver by the process of osmotic displacement. Development of ethylcellulose coating on osmotic pump tablets. Development of ethylcellulose coating on osmotic pump. Asian journal of research in chemistry and pharmaceutical sciences. The in vitro dissolution studies indicated that the osmotic pump tablet combined with msns was able to deliver fenofibrate in an approximately. But conventional drug delivery system does not control the release of drug and provides immediate release of drug. This finding confirms that the mechanism of drug release is by the osmotic pressure. Continuous ophthalmic treatment using an osmotic pump in a bull. Intarcia therapeutics, a company based in boston, ma, is showing off its new medici drug delivery system. L oros hard cap, l oros soft cap and delayed liquid bolus delivery system, telescopic capsule, 23 oros ct, 24 sandwiched osmotic. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the. Save time by eliminating the need for frequent animal handling.
This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of experimental agents. If your research requires an additional injection or chronic administration while using an osmotic pump, we offer a guide osmotic pump cannula. The osmotic pump of claim 7, wherein at least 1 microgram of active agent is used. After filling the pump body with angii, the flow moderator is inserted to seal the pump. The alzet mini osmotic pump model 2002 delivers solutions continuously for at least 14 days without the need for external connections or frequent handling of animals. An infusion pump infuses fluids, medication or nutrients into a patients circulatory system. It is not to be placed into animals used for food or food products, or in humans. Nov 06, 1990 the osmotic pump of claim 1, wherein said water insoluble wall is 1 to 1,000 microns thick and wherein 5 to 95% of the resulting wall pores are between 10 angstroms and 100 microns in diameter. Complete micro osmotic pump system with flow moderator in place 1. Nude mice received either subcutaneously implanted alzet pumps with either colored blue or teal or white flow moderators or no pumps control group. The tool offers drug delivery independent of physiological factors like gastric health, ph, and hydrodynamic conditions. Formulation and evaluation of osmotic pump delivery of. The high osmolality of the salt sleeve causes water to flux into the pump through a semipermeable membrane which forms the outer surface of the pump. Individual lots of pumps may vary from this target within limits.
Some pump models are small enough to be implanted in mice and young rats. For studies requiring chronic dosing, alzet osmotic pumps offer a reliable and convenient alternative to injections and other repetitive dosing methods. The elementary osmotic pump eop was developed by alza in 1974, and was the first practical example of an osmotic pump based drug release system for oral use. The rate and extent of drug absorption from conventional formulations change significantly depending on factors such as. Sandhya1, 2, 1hameeda zareen durani, zaara majeed1, y. Osmotic pump lab 1 university of utah department of. Drug release from novel drug delivery systems are desired to be controlled at target site in effective concentration for required therapeutic action with predictable plasma concentrations, unlike conventional ones, thereby reducing the dose, dosage frequency, toxic adverse effects, reduction of blood level fluctuations, improved patient. One layer the upper layer contains drug in a formulation of polymeric, osmotic agent, and other tablet excipients. Cd, which acts as both a solubilizer and as an osmotic agent. Ultrafast highpressure ac electroosmotic pumps for portable. Osmotic drug delivery system, osmotic pressure controlled formulation, pulsatile drug delivery systems, and sandwich osmotic system. Infusion pumps can administer fluids in ways that would be impractically expensive or unreliable if performed manually by nursing staff. Dosage variability can be achieved by modifying agent concentration. The core of the tablets was prepared by direct compression technique and.
From implant to sandwiched oral therapeutic system. The osmotic pumps consist of a cylindrical reservoir for the fluid, surrounded by a layer of. The porous osmotic pump contains pore forming water soluble additive poly ethylene glycol 400 in the coating membrane which after coming in contact with water, dissolve, resulting in an in situ. The osmoticcontrolled release oral delivery system, oros, is an advanced drug delivery technology that uses osmotic pressure as the driving force to deliver pharmacotherapy, usually oncedaily, in several therapeutic areas.
Describes the principle involved in an osmotic pump used to extract fresh water from the oceans and in an osmotic power plant used to generate electricity. Development and optimization of buspirone oral osmotic pump tablet. Objectives develop an ethylcellulose ecbased coating formulation for glipizide. A new electroosmotic pump based on silica monoliths. Pdf development of an osmotic pump system for controlled.
Technical description of the alzet micro osmotic pump model 1004 a. Pushpull osmotic pump is delivered both poorly water soluble and highly water soluble drugs at a constant rate. The osmotic release pump ensures roundtheclock delivery of the test molecules at a controlled rate. It provides a continuous subcutaneous infusion of the glp1 agonist, exenatide.
Alza, palo alto, ca was implanted subconjunctivally under the upper eyelid and. Articular cavity, blood vessels, bone, brain solid tissue, brain ventricles, ear, eye, muscle, nerves, spinal cord, stomach, and tumors. The socalled osmotic effective area is the area contacted by the osmotic substances. Full text development of an oral pushpull osmotic pump of. Still holding the pump vertically, slowly insert the flow moderator until the cap is flush with the top of the pump this should displace a small amount of fluid from the filled pump. Conclusion a porous osmotic pumpbased drug delivery system can. By attaching the proper catheter, alzet osmotic pumps can deliver substances into the venous or arterial circulation, into the brain, or into any organ, lumen or solid tissue.
Jun 19, 2014 development and characterization aspects of elementary osmotic pump tablets are explained this book. The pumping rate of the model 2ml4 alzet osmotic pump over time in vitro and in vivo in sprague dawley rats after subcutaneous implantation n105. The package consists of a drug pump about the size of a wooden match, a delivery system. One application of this is removing liquid flooding water from channels and gas diffusion layers and direct hydration of the proton exchange membrane in the membrane electrode assembly mea of the proton exchange membrane fuel cells. Empty reservoir within the core of the pump is filled with the drug or hormone solution to be delivered and is surrounded by salt chamber with impermeable layer between them it is an implantable osmotic pumps for laboratory animal the pump are used to deliver homogenous solution or suspension continuously at a. Formulation and in vitro evaluation of sustained release.
An electroosmotic pump eop, or eo pump, is used for generating flow or pressure by use of an electric field. The pumps function through an osmotic gradient between the pump and the tissue where the pump is implanted. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery. Abstract the elementary osmotic pump is a new delivery system for drugs or other active agents. Technical description of the alzet micro osmotic pump model 1002 a. Oral route 1 is a convenient route for the administration of various drugs because of low cost and ease of administration to the patients.
Alzet osmotic pumps are small, selfpowered, infusion pumps for. Miniature osmotic delivery systems were constructed and tested in various environments according to the design criteria described in the present paper. Recent advances include various specific types of osmotic pump systems such as controlled porosity osmotic pump 20 cpop, osmotic bursting osmotic pump 21 obop, liquid orosliquid oral osmotic system 22 e. Ganesh kumar3 1 department of pharmaceutics, shadan womens college of pharmacy, hyderabad, 500004, andhra pradesh, india. Alzet osmotic pumps implantable infusion pumps for. Ultrafast highpressure ac electro osmotic pumps for portable biomedical microfluidics chienchih huang1,2,3,4, martin z. Although shown to be thermodynamically feasible, the osmotic principle is not likely to be used commerically for these purposes in the near future. Healthcare providers can easily install this device into the subdermis of the abdominal wall. A new electroosmotic pump based on silica monoliths ping wang, zilin chen, hsuehchia chang. The purpose of this study was to develop a controlledporosity osmotic pump tablet opt which exhibits phindependent release profiles for a basic drug using a sulfobutyl ether. Exenatide osmotic minipump safety and efficacy for. This product is for use in experimental animals only. Pushpull osmotic pump is a modification of eop figure 8.
Pumps are to be implanted with the animal under general anesthesia. The pumping rate of the model 2002 alzet osmotic pump over time n20. Mouse procedures\ osmotic pumps saha cardiovascular. The alzet osmotic pump model 2ml4 delivers solutions. Miniosmotic pumps alzet 2001, 2004, 2006 or microosmotic pumps alzet. Institute for soldier nanotechnologies, massachusetts institute of technology. Design and evaluation of an osmotic pump tablet opt for. Open only the number of pumps and flow regulators needed for the study, as these cannot be stored once opened. This system resembles a standard bilayer coated tablet.
Articular cavity, blood vessels, bone, brain solid tissue, brain ventricles, ear, eye, muscle, nerves. Journal of pharmaceutics and pharmacology research auctores. Osmosis refers to the process of movement of solvent from lower concentration of solute towards higher concentration of solute across a semipermeable membrane. Natural oils from your hands may damage the exterior of the. The alzet brain infusion kit 2 is designed for use with alzet pumps for local delivery of test solutions to the central nervous system cns. Durect corporation alzet osmotic no 1004 pump alzet osmotic. Asian journal of research in chemistry and pharmaceutical. The historical development of osmotic systems includes development of the rosenelson pump, the higuchi. Jul 17, 2012 pushpull osmotic pump is a modification of eop figure 8. P1 technologies knows the importance of quality and accuracy in research and that time is often a high priority in a critical study. May 26, 2016 this video showing osmotic pump insertion for drug delivery. Subcutaneous angiotensin ii infusion using osmotic pumps. Osmotic drug delivery uses the osmotic pressure for controlled delivery of drugs by using osmogens for upto 10 16 hrs. Alzet osmotic pumps model 2001 were filled with 240.
Maximize therapeutic efficacy and reduce adverse effects. Development and characterization aspects of elementary osmotic pump tablets are explained this book. Understand the engineering principles behind and function of osmotic pump delivery systems. Formulation and evaluation of osmotic pump delivery of oxybutynin. Ultrafast highpressure ac electroosmotic pumps for portable biomedical microfluidics chienchih huang1,2,3,4, martin z. Alzet pumps deliver by the process of osmotic displacement. Osmotic drug delivery system as a part of modified release. Alzet pumps have been exposed to a sterilizing dose of radiation from a 60co source.
A what is osmotic pressure osmotic pressure is a most important colligative property according to pharma point of view. These pumps operate on osmotic pressure difference between a compartment within the pump, called the salt sleeve and the tissue environment in which the pump is implanted. Such delivery systems are based on the principle of osmosis. Rose and nelson developed an implantable pump in 1955. Oral route is one of the most extensively used routes of. The nominal performance is a target for all pumps manufactured. Durect corporation alzet osmotic no 1004 pump alzet. Durect corporation alzet osmotic pump model 1002 alzet. Principles of the design and operation of generic osmotic. The osmotic pump was successfully developed using symmetric membrane coating.
International journal of pharmtech research, januarymarch 2010. Controlled porosity osmotic pumps cpop are similar to elementary osmotic pump, the only difference being that the delivery orifice from which. Formulation and in vitro evaluation of sustained release tablets of venlafaxine hydrochloride by porous osmotic technology pamu. This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of. This video showing osmotic pump insertion for drug delivery.
It was introduced to the market in the early 1980s in osmosin indomethacin and acutrim phenylpropanolamine, but unexpectedly severe issues with gi irritation and cases of gi perforation led to the withdrawal of osmosin. One method of achieving this goal is to deliver a large excess of agent. Osmoticcontrolled release oral delivery system wikipedia. Zeroorder drug release after an initial tag is one of the significant advantages of the implantable osmotic release pump. Verify that the flow moderator is fully inserted into the pump.
Ultrafast highpressure ac electroosmotic pumps for. The alzet product line consists of miniature implantable pumps and a range of accessories for experimental research in mice, rats, and other laboratory animals. Convenient and reliable alternative to frequent injections. The elementary osmotic pump is a new delivery system for drugs or other active agents. With alzet pumps, drug administration continues, around the clock, for up to 6 weeks with a single pump, and the duration can be extended for multiple months through serial implantation. The osmoticcontrolled release oral delivery system oros is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semipermeable outer membrane and one or more small laser drilled holes in it. Alzet pumps continuously deliver drugs, hormones, and other test agents at controlled rates for durations ranging from 1 day to 6 weeks. The historical development of osmotic systems includes development of the rose nelson pump, the higuchileeper pumps, the alzet and osmet. Understand the calculation of mass balance from an osmotic pump over the time course of a drug release experiment. It is therefore possible to cal culate the osmotic pressure of a given solution, first, on the assumption that vant hoffs law is correct, and second, on the assumption that raoults law2 is correct. The in vitro pumping rate of the model 1003d alzet osmotic pump over time n20. July september 9 the unique feature of semipermeable membrane utilized for an osmotic pump is that it permits. International journal of research in pharmaceutical and biomedical sciences, july september 20.